The dissemination of tumor cells to local and distant sites presents a significant challenge in
the clinical management of many solid tumors. These cells may remain dormant for months …

Cumulative evidence indicates that a significant proportion of cancer evolution may occur
before the development of histological abnormalities. While recent improvements in DNA …

Pre-symptomatic screening of genetic alterations might help identify subpopulations of
individuals that could enter into early access prevention programs. Since liquid biopsy is …

Bronchial premalignant lesions (PMLs) are precursors of lung squamous cell carcinoma, but
have variable outcome, and we lack tools to identify and treat PMLs at risk for progression to …

Driver mutations alter cells from normal to cancer through several evolutionary epochs:
premalignancy, early malignancy, subclonal diversification, metastasis and resistance to …

Objectives Oral leukoplakia (OLK) is one of the most common oral potentially malignant
lesions (OPMD) and is reported to undergo malignant transformation (MT) to oral squamous …

Lung cancer survival statistics are sobering with survival ranking among the poorest of all
cancers despite the addition of targeted therapies and immunotherapies. However …

Lung cancer remains the leading cause of cancer-related death due to its advanced stage at
diagnosis. Early detection of lung cancer can be improved by better defining who should be …

While there is considerable interest at the present time in the development of so-called liquid
biopsy approaches for cancer detection based notably on circulating tumor DNA, there are …

Squamous cell carcinoma (SCC), one of the most common forms of lung cancer, shows
accelerated progression and aggressive growth and usually is observed at advanced …