The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms

J Böhning, AK Tarafder, TAM Bharat - Biochemical Journal, 2024 - portlandpress.com
Numerous bacteria naturally occur within spatially organised, multicellular communities
called biofilms. Moreover, most bacterial infections proceed with biofilm formation, posing …

Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa

J Böhning, AW Dobbelstein, N Sulkowski… - PLoS …, 2023 - journals.plos.org
Chaperone-Usher Pathway (CUP) pili are major adhesins in Gram-negative bacteria,
mediating bacterial adherence to biotic and abiotic surfaces. While classical CUP pili have …

Phage-induced “one-to-many” FRET sensor for highly sensitive detection of Escherichia coli O157: H7

M Meng, X Ma, L Yu, X Zhang, Y Chen, W Li… - Biosensors and …, 2024 - Elsevier
As a foodborne pathogen capable of causing severe illnesses, early detection of
Escherichia coli O157: H7 (E. coli O157: H7) is crucial for ensuring food safety. While Förster …

The Inovirus Pf4 Triggers Antiviral Responses and Disrupts the Proliferation of Airway Basal Epithelial Cells

MC Popescu, NL Haddock, EB Burgener… - Viruses, 2024 - mdpi.com
Background: The inovirus Pf4 is a lysogenic bacteriophage of Pseudomonas aeruginosa
(Pa). People with Cystic Fibrosis (pwCF) experience chronic airway infection with Pa and a …

Probing elastic anisotropy on entropic interfaces

Y Yuan, P Azzari, R Mezzenga - Physical Review Research, 2024 - APS
Liquid-liquid phase separation is vital in the formation of many biomolecular condensates,
including cellular membraneless organelles. When semiflexible macromolecules are …

Modelling the effects of charge on antibiotic diffusion and adsorption in liquid crystalline virus suspensions

MT van Rossem, S Wilks, M Kaczmarek… - Soft Matter, 2024 - pubs.rsc.org
We develop a microscopic model of antibiotic diffusion in virus suspensions in a liquid
crystalline state. We then approximate this with an effective homogenised model that is more …

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus

H Ochner, J Boehning, Z Wang, AK Tarafder, I Caspy… - bioRxiv, 2024 - biorxiv.org
Type IV pili (T4Ps), which are abundant in many bacterial and archaeal species, have been
shown to play important roles in both surface sensing and twitching motility, with implications …