An update on the genetics of hyperuricaemia and gout
A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …
the formation of monosodium urate crystals. The clinical features of gout result from an …
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
A general approach for haplotype phasing across the full spectrum of relatedness
Many existing cohorts contain a range of relatedness between genotyped individuals, either
by design or by chance. Haplotype estimation in such cohorts is a central step in many …
by design or by chance. Haplotype estimation in such cohorts is a central step in many …
Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers
Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating
binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we …
binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we …
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Smoking is a leading global cause of disease and mortality. We established the Oxford-
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for
cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 …
cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 …
The genetics of obesity and the metabolic syndrome
K L. Monda, K E. North, S C. Hunt… - … Metabolic & Immune …, 2010 - benthamdirect.com
In this review, we discuss the genetic architecture of obesity and the metabolic syndrome,
highlighting recent advances in identifying genetic variants and loci responsible for a portion …
highlighting recent advances in identifying genetic variants and loci responsible for a portion …
CUBN is a gene locus for albuminuria
Identification of genetic risk factors for albuminuria may alter strategies for early prevention
of CKD progression, particularly among patients with diabetes. Little is known about the …
of CKD progression, particularly among patients with diabetes. Little is known about the …