Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains
attached to their extracellular domain. Like many proteoglycans, they interact with a large …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) comprise a heterogeneous group of
pharmacological agents used for the symptomatic treatment of fever, pain, and inflammation …

The skin is colonized by a plethora of microbes that include commensals and potential
pathogens, but it is currently unknown how cutaneous host immune mechanisms influence …

The aim of this review is to give an overview of the extracellular matrix (ECM) components
that are important for creating structural changes in the premetastatic and metastatic niche …

Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating
several human cancers. We recently showed that eosinophils play an essential role in anti …

Allergic conjunctivitis (AC) is a common condition resulting from exposure to allergens such
as pollen, animal dander, or mold. It is typically mediated by allergen-induced crosslinking of …

Precise spatiotemporal regulation of leukocyte extravasation is key for generating an
efficient immune response to injury or infection. The integrins LFA-1 (CD11a/CD18) and Mac …

Cancer is the second leading cause of mortality worldwide. Skin cancer is the most common
cancer in South Africa with nearly 20,000 reported cases every year and 700 deaths. If …

Here, we discuss pathophysiological approaches to the defining of endothelial dysfunction
criteria (ie, endothelial activation, impaired endothelial mechanotransduction, endothelial-to …

Cancer progression and metastasis are processes heavily controlled by the integrin receptor
family. Integrins are cell adhesion molecules that constitute the central components of …