Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when
injury is severe or persistent, the repair is incomplete or maladaptive and may lead to …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

Platelet derived growth factor (PDGF) signaling plays an important role in activated hepatic
stellate cells and portal fibroblast proliferation, chemotaxis, migration and cell survival …

The PDGF system, comprising four isoforms (PDGF-A,-B,-C, and-D) and two receptor chains
(PDGFR-α and-β), plays important roles in wound healing, atherosclerosis, fibrosis, and …

Renal inflammation is the initial, healthy response to renal injury. However, prolonged
inflammation promotes the fibrosis process, which leads to chronic pathology and eventually …

Accumulating evidence indicates that inflammatory and immunologic processes play a
significant role in the development and progression of glomerular diseases. Podocytes, the …

Chronic kidney disease (CKD) is a major health and economic burden with a rising
incidence. During progression of CKD, the sustained release of proinflammatory and …

Glomerular diseases are the leading causes of chronic and end-stage kidney disease. In the
1980s and 1990s, attention was focused on the biology and role of glomerular endothelial …