Current perspectives of the applications of polyphenols and flavonoids in cancer therapy

X Montané, O Kowalczyk, B Reig-Vano, A Bajek… - Molecules, 2020 - mdpi.com
The development of anticancer therapies that involve natural drugs has undergone
exponential growth in recent years. Among the natural compounds that produce beneficial …

Apigenin in cancer prevention and therapy: a systematic review and meta-analysis of animal models

D Singh, M Gupta, M Sarwat, HR Siddique - Critical reviews in oncology …, 2022 - Elsevier
Background Apigenin is being increasingly recognized as a cancer chemopreventive agent.
We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its …

Therapeutical properties of apigenin: A review on the experimental evidence and basic mechanisms

Z Mushtaq, NB Sadeer, M Hussain… - … Journal of Food …, 2023 - Taylor & Francis
ABSTRACT Apigenin (4,'5, 7-trihydroxyflavone) is one of the most studied flavonoids with
low toxicity and abundantly present phenolic compound in the plant kingdom. The main …

Revisiting inorganic nanoparticles as promising therapeutic agents: A paradigm shift in oncological theranostics

MA Khan, D Singh, A Ahmad, HR Siddique - European Journal of …, 2021 - Elsevier
Cancer remains a global health problem largely due to a lack of effective therapies. Major
cancer management strategies include chemotherapy, surgical resection, and radiation …

Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives

P Chen, F Chen, ZL Guo, J Lei, B Zhou - Frontiers in Nutrition, 2023 - frontiersin.org
Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and
possesses biological activities that protect against immune, cardiovascular, and …

Apigenin analogues as SARS-CoV-2 main protease inhibitors: In-silico screening approach

A Farhat, H Ben Hlima, B Khemakhem… - …, 2022 - Taylor & Francis
The COVID-19 new variants spread rapidly all over the world, and until now scientists strive
to find virus-specific antivirals for its treatment. The main protease of SARS-CoV-2 (Mpro) …

Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects

D Singh, MA Khan, HR Siddique - Phytotherapy Research, 2024 - Wiley Online Library
Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds,
biological agents, and medical products. These reactions can manifest as acute or chronic …

Accentuating CircRNA-miRNA-transcription factors axis: a conundrum in cancer research

D Singh, P Kesharwani, NA Alhakamy… - Frontiers in …, 2022 - frontiersin.org
Circular RNAs (circRNAs) are the newly uncovered class of non-coding RNAs being
cognized as profound regulators of gene expression in developmental and disease biology …

Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress

D Singh, MA Khan, K Akhtar, F Arjmand… - Toxicology and Applied …, 2022 - Elsevier
Sorafenib is an FDA-approved chemotherapeutic drug used as standard therapy for
advanced-stage cancers. However, Sorafenib-induced multiple adverse effects are a major …

Therapeutic implications of probiotics in microbiota dysbiosis: A special reference to the liver and oral cancers

D Singh, MA Khan, HR Siddique - Life Sciences, 2021 - Elsevier
The microbiota plays an important role in maintaining the body's homeostasis. Imbalance in
the microbiota is referred to as microbiota dysbiosis. Microbiota dysbiosis leads to pro …