The incidence of early-onset colorectal cancer (CRC), which occurs in individuals< 50 years
of age, has been increasing worldwide and particularly in high-income countries. The …

Population stratification is a useful approach for a better understanding of complex
biological problems in human health and wellbeing. The proposal that such stratification …

Background There is increasing evidence that metastatic colorectal cancer (mCRC) is a
genetically heterogeneous disease and that tumours arising from different sides of the colon …

Background Retrospective subgroup analyses suggest that primary tumour location (PTL)
has a prognostic importance and relates to response to targeted therapy. Methods We …

Objective Accumulating evidence links the intestinal microbiota and colorectal
carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

Diet has an important role in the development of colorectal cancer. In the past few decades,
findings from extensive epidemiologic and experimental investigations have linked …

Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Purpose: Colorectal cancers are classified as right/left-sided based on whether they occur
before/after the splenic flexure, with established differences in molecular subtypes and …