[HTML][HTML] The evolution of neurofilament light chain in multiple sclerosis

C Ferreira-Atuesta, S Reyes, G Giovanonni… - Frontiers in …, 2021 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the
central nervous system characterized by demyelination and axonal damage. Diagnosis and …

Body fluid biomarkers in multiple sclerosis

M Comabella, X Montalban - The Lancet Neurology, 2014 - thelancet.com
Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological
disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of …

Neurofilaments as biomarkers in multiple sclerosis

CE Teunissen, M Khalil - Multiple sclerosis journal, 2012 - journals.sagepub.com
Neurodegeneration is the correlate of disease progression in multiple sclerosis (MS) and
thus biological biomarkers that sensitively reflect this process are much needed …

[HTML][HTML] B cells are multifunctional players in multiple sclerosis pathogenesis: insights from therapeutic interventions

N Claes, J Fraussen, P Stinissen, R Hupperts… - Frontiers in …, 2015 - frontiersin.org
Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS)
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

D Wheeler, VVR Bandaru, PA Calabresi, A Nath… - Brain, 2008 - academic.oup.com
Maintaining the appropriate complement and content of lipids in cellular membranes is
critical for normal neural function. Accumulating evidence suggests that even subtle …

Disease biomarkers in multiple sclerosis: potential for use in therapeutic decision making

VK Harris, SA Sadiq - Molecular diagnosis & therapy, 2009 - Springer
Multiple sclerosis (MS) is an autoimmune disorder of the brain and spinal cord that
predominantly affects white matter. MS has a variable clinical presentation and has no …

Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

A Malaspina, F Puentes, S Amor - International immunology, 2015 - academic.oup.com
The immune system is inextricably linked with many neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor …

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

M van Zwam, R Huizinga, MJ Melief… - Journal of molecular …, 2009 - Springer
Drainage of central nervous system (CNS) antigens to the brain-draining cervical lymph
nodes (CLN) is likely crucial in the initiation and control of autoimmune responses during …

Biomarkers of therapeutic response in multiple sclerosis: current status

VK Harris, SA Sadiq - Molecular diagnosis & therapy, 2014 - Springer
Multiple sclerosis (MS) is an autoimmune disease of unknown cause, in which chronic
inflammation drives multifocal demyelination of axons in both white and gray matter in the …

Targets of the humoral autoimmune response in multiple sclerosis

J Fraussen, N Claes, L de Bock, V Somers - Autoimmunity reviews, 2014 - Elsevier
Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system (CNS) with
heterogeneous clinical, genetic and pathophysiological characteristics. The establishment of …