The aryl hydrocarbon receptor (AhR) as a breast cancer drug target
JR Baker, JA Sakoff… - Medicinal research reviews, 2020 - Wiley Online Library
Breast cancer is the most common cancer in women, with more than 1.7 million diagnoses
worldwide per annum. Metastatic breast cancer remains incurable, and the presence of …
worldwide per annum. Metastatic breast cancer remains incurable, and the presence of …
[HTML][HTML] Insights into the toxicities of UV-328, UV-329, UV-P in HepG2 cells and their roles in AHR-mediated pathway
S Liang, Y Zhang, H Bo, W Duan, L Zhong - … and Environmental Safety, 2023 - Elsevier
The widespread high concentrations of benzotriazole ultraviolet stabilizers (BUVSs) in many
biotic and abiotic samples have raised urgent concerns of their adverse effects on …
biotic and abiotic samples have raised urgent concerns of their adverse effects on …
Amino alcohol acrylonitriles as activators of the aryl hydrocarbon receptor pathway: An unexpected MTT phenotypic screening outcome
JR Baker, CC Russell, J Gilbert, JA Sakoff… - …, 2020 - Wiley Online Library
Abstract Lead (Z)‐N‐(4‐(2‐cyano‐2‐(3, 4‐dichlorophenyl) vinyl) phenyl) acetamide, 1
showed MCF‐7 GI50= 30 nM and 400‐fold selective cf MCF10A (normal breast tissue) …
showed MCF‐7 GI50= 30 nM and 400‐fold selective cf MCF10A (normal breast tissue) …
Alizarin, an Agonist of AHR Receptor, Enhances CYP1A1 Enzyme Activity and Induces Transcriptional Changes in Hepatoma Cells
S Liang, H Bo, Y Zhang, H Zhen, L Zhong - Molecules, 2023 - mdpi.com
The phytopigment alizarin was previously characterized as an anti-tumor drug owing to its
antioxidant or antigenotoxic activities. However, the safety of alizarin is currently still under …
antioxidant or antigenotoxic activities. However, the safety of alizarin is currently still under …
Development and interpretation of a QSAR model for in vitro breast cancer (MCF-7) cytotoxicity of 2-phenylacrylonitriles
DT Stanton, JR Baker, A McCluskey… - Journal of Computer-Aided …, 2021 - Springer
Abstract The Arylhydrocarbon Receptor (AhR), a member of the Per-ARNT-SIM transcription
factor family, has been as a potential new target to treat breast cancer sufferers. A series of 2 …
factor family, has been as a potential new target to treat breast cancer sufferers. A series of 2 …