The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour
of phagocytic cells of the innate immune system, especially macrophages and neutrophils …

Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Fungi must meet four criteria to infect humans: growth at human body temperatures,
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …

The outcome of cryptococcal pneumonia correlates with local macrophage polarization
status, as M1 and M2 polarization marks protective and nonprotective responses …

The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the
passage of molecules and microorganisms. Despite this barrier, however, the fungal …

Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

Most of the fungal species that infect humans can grow in more than one morphological form
but only a subset of pathogens produce filamentous hyphae during the infection process …