The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …

The wingless/int1 (WNT)/F rizzled (FZD) signalling pathway controls numerous cellular
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …

Tumor-associated macrophages (TAMs) are a major component of tumor microenvironment
(TME) and play pivotal roles in the progression of hepatocellular carcinoma (HCC). Wnt …

The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes
throughout development and adult life. Growing evidences have suggested that …

Inflammasome activation plays a crucial role in the progression to more severe stages of
non-alcoholic fatty liver disease (NAFLD), representing a promising therapeutic target …

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder
accompanied by chronic low-grade inflammation, but the molecular mechanism remains …

Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance in
obese individuals. Cell culture studies and gain-of-function mouse models suggest that …

Innate immunity against pathogenic bacteria is critical to protect host cells from invasion and
infection as well as to develop an appropriate adaptive immune response. During bacterial …

Wnt proteins are secreted, palmitoylated glycoproteins with multiple functions in cell
proliferation and migration as well as tissue organization. They are best known for their role …

Embryonic lung development requires reciprocal endodermal-mesodermal interactions;
mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the …