Optimal control and the Pontryagin's principle in chemical engineering: History, theory, and challenges

O Andrés‐Martínez, O Palma‐Flores… - AIChE …, 2022 - Wiley Online Library
In the mid‐1950s, Pontryagin et al. published a principle that became a fundamental
concept in optimal control (OC) theory. The principle provides theoretical and practical …

Production of microalgae biomass in a continuous stirred bioreactor: Analysis of microalgae-bacteria competition mediated by nitrogen and organic carbon

P Altimari, A Brasiello, F Di Caprio… - Chemical Engineering …, 2022 - Elsevier
A model-based analysis of the competition between microalgae and bacteria mediated by
nitrogen and organic carbon in a continuous bioreactor with recycle is presented. The …

Modelado y control de la producción de microalgas en fotobiorreactores industriales

JL Guzmán, FG Acién… - Revista Iberoamericana de …, 2021 - polipapers.upv.es
Este artículo presenta una visión general sobre el proceso de producción de microalgas
desde un punto de vista de modelado y control de procesos. En primer lugar se exponen las …

Optimal darwinian selection of microorganisms with internal storage

W Djema, T Bayen, O Bernard - Processes, 2022 - mdpi.com
In this paper, we investigate the problem of species separation in minimal time. Droop model
is considered to describe the evolution of two distinct populations of microorganisms that are …

[HTML][HTML] Production of microalgae biomass in a two-stage continuous bioreactor: Control of microalgae-bacteria competition by spatial uncoupling of nitrogen and …

P Altimari, F Di Caprio, A Brasiello… - Chemical Engineering …, 2023 - Elsevier
The spatial uncoupling of nitrogen and organic carbon is proposed to control the competition
between microalgae and bacteria in continuous bioreactors. A series of two continuous …

Turnpike features in optimal selection of species represented by quota models

W Djema, L Giraldi, S Maslovskaya, O Bernard - Automatica, 2021 - Elsevier
The paper focuses on a generic optimal control problem (OCP) deriving from the competition
between two microbial populations in continuous cultures. The competition for nutrients is …

A practical cell density stabilization technique through drug infusions: a simple pathfinding approach

W Djema, C Bonnet, H Özbay… - 2023 European Control …, 2023 - ieeexplore.ieee.org
We consider a nonlinear system with distributed delays modeling cell population dynamics,
where the parameters depend on growth-factor concentrations. A change in one of the …

Optimal control separating two microalgae species competing in a chemostat

W Djema, O Bernard, T Bayen - 2020 59th IEEE Conference on …, 2020 - ieeexplore.ieee.org
In this work, we study the question of selecting in minimal-time a microalgae species of
interest using the Droop model to describe the dynamics of two distinct populations …

Time-optimal adaptation in metabolic network models

MA Köbis, A Bockmayr, R Steuer - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Analysis of metabolic models using constraint-based optimization has emerged as an
important computational technique to elucidate and eventually predict cellular metabolism …

Turnpike features in optimal selection of species represented by quota models: extended proofs

W Djema, L Giraldi, S Maslovskaya, O Bernard - 2021 - hal.science
The paper focuses on a generic optimal control problem (OCP) deriving from the competition
between two microbial populations in continuous cultures. The competition for nutrients is …