Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance
MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer
NG Steele, ES Carpenter, SB Kemp, VR Sirihorachai… - Nature Cancer, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor
microenvironment that renders it largely refractory to immunotherapy. We implemented a …
microenvironment that renders it largely refractory to immunotherapy. We implemented a …
Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
Cancer-associated fibroblasts (CAF) are major players in the progression and drug
resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell …
resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell …
[HTML][HTML] Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer
Here, we utilized spontaneous models of pancreatic and lung cancer to examine how
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
T Zhang, Y Ren, P Yang, J Wang, H Zhou - Cell Death & Disease, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …
Regulatory T-cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis
Y Zhang, J Lazarus, NG Steele, W Yan, HJ Lee… - Cancer discovery, 2020 - AACR
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To
understand the contribution to the immunosuppressive microenvironment, we depleted …
understand the contribution to the immunosuppressive microenvironment, we depleted …
Broadening the impact of immunotherapy to pancreatic cancer: challenges and opportunities
VP Balachandran, GL Beatty, SK Dougan - Gastroenterology, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer in the United States by 2025, with 5-year survival at less than 10%. In other …
cancer in the United States by 2025, with 5-year survival at less than 10%. In other …
Epithelial and stromal co-evolution and complicity in pancreatic cancer
SR Hingorani - Nature Reviews Cancer, 2023 - nature.com
Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
[HTML][HTML] Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells
CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …