Dopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The
dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is …

Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …

Mitochondrial dysfunction may play a crucial role in various diseases due to its roles in the
regulation of energy production and cellular metabolism. Serine/threonine kinase (AKT) is a …

Protein expression abnormalities have been implicated in the pathophysiology of
schizophrenia, but the underlying cause of these changes is not known. We sought to …

Abnormal neurotransmission is central to schizophrenia (SZ). Alterations across multiple
neurotransmitter systems in SZ suggest that this illness may be associated with …

Background Patients with bipolar disorder (BD) suffer from greater physical morbidity and
mortality than the general population. The aim of the present study is to explore the …

Neuroprotective therapies which focus on factors leading to retinal ganglion cells (RGCs)
degeneration have been drawing more and more attention. The beneficial effects of nerve …

Schizophrenia and autism have been linked since their earliest descriptions. Both are
disorders of cerebral specialization originating in the embryonic period. Genetic, molecular …

Dendrite morphology is pivotal for neural circuitry functioning. While the causative
relationship between small-scale dendrite morphological abnormalities (shape, density of …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …