Anti-islet autoantibodies in type 1 diabetes

E Kawasaki - International Journal of Molecular Sciences, 2023 - mdpi.com
Anti-islet autoantibodies serve as key markers in immune-mediated type 1 diabetes (T1D)
and slowly progressive T1D (SPIDDM), also known as latent autoimmune diabetes in adults …

Heat-shock proteins induce T-cell regulation of chronic inflammation

W Van Eden, R Van der Zee, B Prakken - Nature Reviews Immunology, 2005 - nature.com
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory
diseases; however, the significance of such responses is only now becoming clear. In …

A comprehensive guide to antibody and T‐cell responses in type 1 diabetes

SM Lieberman, TP DiLorenzo - Tissue antigens, 2003 - Wiley Online Library
Type 1 diabetes (T1D) is an organ‐specific autoimmune disease in which the insulin‐
producing β cells in the pancreatic islets are selectively eliminated. T cells specific for β‐cell …

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

F Waldron-Lynch, KC Herold - Nature Reviews Drug Discovery, 2011 - nature.com
Type 1 diabetes is a common, severe chronic autoimmune disease that is characterized by
the progressive and insidious loss of self-tolerance to the insulin-producing pancreatic islet …

[HTML][HTML] Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?

T Wu, RM Tanguay - Cell stress & chaperones, 2006 - ncbi.nlm.nih.gov
Heat shock proteins (Hsps) can be found in two forms, intracellular and extracellular. The
intracellular Hsps are induced as a result of stress and have been found to be cytoprotective …

A common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: Inflammation in their induction and impact on tumor growth

R Bei, L Masuelli, C Palumbo, M Modesti, A Modesti - Cancer letters, 2009 - Elsevier
The repertoire of autoantibodies found in cancer patients partly overlaps with that typical of
patients with autoimmune diseases. Beside the biochemical and immunological properties …

Treatment of new‐onset type 1 diabetes with peptide DiaPep277® is safe and associated with preserved beta‐cell function: extension of a randomized, double‐blind …

I Raz, A Avron, M Tamir, M Metzger… - Diabetes/metabolism …, 2007 - Wiley Online Library
Abstract Background Treatment with DiaPep277®, a peptide derived from HSP60, has been
shown to preserve beta‐cell function in non‐obese diabetic mouse (NOD) mice and in a trial …

The role of heat shock proteins in type 1 diabetes

ASM Moin, M Nandakumar, A Diane, M Dehbi… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by
recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs) …

[HTML][HTML] A master autoantigen-ome links alternative splicing, female predilection, and COVID-19 to autoimmune diseases

JY Wang, MW Roehrl, VB Roehrl, MH Roehrl - Journal of Translational …, 2022 - Elsevier
Chronic and debilitating autoimmune sequelae pose a grave concern for the post-COVID-19
pandemic era. Based on our discovery that the glycosaminoglycan dermatan sulfate (DS) …

Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs)

T Koliński, N Marek-Trzonkowska… - … European Journal of …, 2016 - termedia.pl
Heat shock proteins (HSPs) belong to the family of conservative polypeptides with a high
homology of the primary structure. The uniqueness of this family lies in their ability to interact …