The process of translation requires substantial cellular resources. Cells have therefore
evolved complex mechanisms to control overall protein synthesis as well as the translation …

The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-
signaling pathways commonly deregulated in human cancers. This has led to the prediction …

Abstract mTOR (mammalian target of rapamycin) has come a long way since its humble
beginnings as a kinase of unknown function. As part of the mTORC1 and mTORC2 …

Ubiquitin proteasome system (UPS) and autophagy lysosome pathway (ALP) are the two
most important routes for degradation of aggregated/misfolded proteins. Additionally, ALP is …

Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …

The precise mechanistic sequence producing the beneficial effects on health and lifespan
seen with interventions as diverse as caloric restriction, intermittent fasting, exercise, and …

Abstract Triple Negative Breast Cancer (TNBC) is a challenging disease due to the lack of
druggable targets; therefore, chemotherapy remains the standard of care and the …

The ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are
the two most important cellular mechanisms for protein degradation. To investigate the role …

Mammalian target of rapamycin (mTOR) is a key protein kinase controlling signal
transduction from various growth factors and upstream proteins to the level of mRNA …

Malignant pleural mesothelioma (MPM) is a progressive malignancy associated to the
exposure of asbestos fibers. The most frequently inactivated tumor suppressor gene in MPM …