Immunological memory is a hallmark of the adaptive immune system. Although natural killer
(NK) cells are innate immune cells important for the immediate host defence, they can …

Genome editing can introduce designed mutations into a target genomic site. Recent
research has revealed that it can also induce various unintended events such as structural …

Copy number variation (CNV) is one of the main sources of variation between different
individuals that has recently attracted much researcher interest as a major source for …

The type I CRISPR system has recently emerged as a promising tool, especially for large-
scale genomic modification, but its application to generate model animals by editing zygotes …

Vesicular trafficking is essential for the transport of intracellularly produced functional
molecules to the plasma membrane and extracellular space. The exocyst complex …

CRISPR-Cas technology has enabled the rapid and effortless generation of genetically
modified mice. Specifically, mice and point mutant mice are readily produced by …

Tunchang pigs, mainly distributed throughout Hainan Province of China, are well-known for
their superior meat quality, crude feed tolerance, and adaptability to high temperatures and …

Microinjection of spermatozoa or spermatids into oocytes is a major choice for infertility
treatment. However, the use of premeiotic spermatocytes has never been considered …

Peroxisomal fatty acyl-CoA reductase 1 (FAR1) is a rate-limiting enzyme for ether lipid (EL)
synthesis. Gene mutations in FAR1 cause a rare human disease. Furthermore, altered EL …

A limited number of female germ cells support reproduction in many mammals. The follicle,
composed of oocytes and supporting granulosa cells, forms the basis of oogenesis …