Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Background State-of-the-art advances have indicated the pivotal characteristics of bone
marrow-derived mesenchymal stem/stromal cells (BM-MSCs) in hematopoietic …

Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that
has an unfavorable outcome and a high rate of relapse. Autophagy plays a vital role in the …

The self-renewal, pluripotency and differentiation of stem cells are regulated by various
genetic and epigenetic factors. As a kind of RNA binding protein (RBP), the heterogeneous …

Abstract Bromodomain-containing protein 9 (BRD9), an essential component of the
SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a …

Despite the development of novel therapies for acute myeloid leukemia, outcomes remain
poor for most patients, and therapeutic improvements are an urgent unmet need. Although …

Acute myeloid leukemia (AML) is a heterogeneous disease associated with various
alterations in T cell phenotype and function leading to an abnormal cell population …

Dysregulation of the epigenetic enzyme-mediated transcription of oncogenes or tumor
suppressor genes is closely associated with the occurrence, progression, and prognosis of …

Acute myeloid leukemia (AML) patients often experience poor therapeutic outcomes and
relapse after treatment with single-target drugs, representing the urgent need of new …