Mild TBI (mTBI) is a significant health concern. Animal models of mTBI are essential for
understanding mechanisms, and pathological outcomes, as well as to test therapeutic …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Background Brain edema as a result of secondary injury following traumatic brain injury
(TBI) is a major clinical concern. Neutrophils are known to cause increased vascular …

Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for
the treatment of asthma in both children and adults. However, its effectiveness is debated …

Eicosanoids are biologically active lipids in both physiologic and pathophysiologic
situations. These mediators rapidly generate at sites of inflammation and act through specific …

The underlying pathology of Alzheimer's disease (AD) is complex and includes, besides
amyloid beta (Aβ) plaque depositions and neurofibrillary tangles, brain atrophy and …

In vitro and preclinical in vivo research in the last 35 years has clearly highlighted the crucial
physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and …

Abstract Background Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are pro-inflammatory
mediators of the 5-lipooxygenase (5-LO) pathway, that play an important role in …

Traumatic brain injury (TBI) contributes to a substantial number of deaths and cases of
permanent disability annually. An immune response to head injury gives a timeline to the …

Alzheimer's disease (AD) is the most common form of dementia. In particular,
neuroinflammation, mediated by microglia cells but also through CD8+ T-cells, actively …