The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic
modifications, has been widely demonstrated in cancer. The complex interplay between …

The emergence of drug resistance and metastasis has long been a difficult problem for
cancer treatment. Recent studies have shown that cancer stem cell populations are key …

Simple Summary Diffuse midline glioma (DMG) is a highly aggressive brain tumor primarily
affecting children and young adults. It grows diffusely in midline structures. Unfortunately …

During the last 20 years, molecular alterations have gained increasing significance in the
diagnosis and biological assessment of tumors. Gliomas represent the largest group of …

Background Metal-responsive transcription factor-1 performs a necessary position in a
range of cancers. It is unknown, though, how the prognosis of patients with low-grade …

Glioblastoma has been extensively studied due to its high mortality and short survival. The
evolution mechanism of tumor-associated macrophages (TAMs) to Glioma-associated …

Abstract Brain tumors, particularly Glioblastoma Multiforme (GBM) and Low-Grade Gliomas
(LGG), present significant clinical challenges due to their aggressive nature and resistance …

The challenges in identifying effective therapies for CNS tumors continue to be daunting.
Potentially effective targeted therapies must be able to penetrate the blood–brain barrier to …

Glioblastoma (GBM) is a heterogenous primary brain tumour that is characterised with
unfavourable patient prognosis. The identification of biomarkers for managing brain …

Abstract CDKN2A/B deletions are prognostically relevant in low-and high-grade gliomas.
Data on this is derived from heterogeneous series, an accurate estimation of survival risk …