The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Gustation or the sense of taste is a primary sense, which functions as a gatekeeper for
substances that enter the body. Animals, including humans, ingest foods that contain …

Oral cancer has a high annual incidence rate all over the world, and the tongue is the most
frequently affected anatomic structure. The current standard care is ablative surgery of …

Taste bud cells regenerate throughout life. Taste bud maintenance depends on continuous
replacement of senescent taste cells with new ones generated by adult taste stem cells …

Taste buds comprise four types of taste cells: three mature, elongate types, Types I–III; and
basally situated, immature postmitotic type, Type IV cells. We employed serial blockface …

Background The role of taste perception in the development and persistence of obesity is
currently unclear due to conflicting results from psychophysical and other studies. No study …

Embryonic taste bud primordia are specified as taste placodes on the tongue surface and
differentiate into the first taste receptor cells (TRCs) at birth. Throughout adult life, TRCs are …

Activation of the Hedgehog pathway may have therapeutic value for improved bone healing,
taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic …

Sensorineural hearing loss is the most prevalent sensory deficit in humans. Most cases of
hearing loss are due to the degeneration of key structures of the sensory pathway in the …

Mutations in SHH and several other genes encoding components of the Hedgehog
signaling pathway have been associated with holoprosencephaly syndromes, with …