Since its first clinical description (on his son) by William James West (1793–1848) in 1841,
and the definition of the classical triad of (1) infantile spasms;(2) hypsarrhythmia, and (3) …

Objective Approximately 50% of patients with tuberous sclerosis complex develop infantile
spasms, a sudden onset epilepsy syndrome associated with poor neurological outcomes …

Introduction Infantile epileptic spasms syndrome (IESS) is a common developmental and
epileptic encephalopathy with poor long-term outcomes. A substantial proportion of patients …

Objective To determine risk factors and causes for mortality during childhood in patients with
infantile spasms (IS). We describe the overall goals of care for those who died. Methods This …

Objective To investigate the potential of EEG multiscale entropy and complexity as
biomarkers in infantile spasms. Methods We collected EEG data retrospectively from 16 …

Introduction: Perinatal arterial ischemic stroke (PAIS) underlies approximately 10% of
infantile spasms (IS). We aim to identify patterns of brain injury in ischemic stroke that may …

Objective Prior surgical series in children with drug-resistant epileptic spasms have reported
use of intracranial EEG monitoring in up to two-third of patients. We report outcome after …

Background Down syndrome (DS) is the most prevalent chromosomal disorder
characterized by intellectual disability, multiple organ anomalies, generalized muscular …

Introduction Even though adrenocorticotropic hormone (ACTH) demonstrated powerful
efficacy in the initially successful treatment of infantile spasms (IS), nearly one-half of …

Background Infantile epileptic spasms syndrome (IESS) is a severe epileptic condition
characterized by persistent uncontrolled seizures, with some children experiencing recurrent …