Liberation of sequestered Ca2+ ions in Xenopus oocytes by the second messenger inositol
1, 4, 5-trisphosphate (InsP3) occurs from functionally discrete sites, which are spaced at …

The three subtypes of inositol trisphosphate (InsP3) receptor expressed in mammalian cells
are each capable of forming intracellular Ca2+ channels that are regulated by both InsP3 …

Abstract The second messenger inositol-1, 4, 5-trisphosphate (InsP3) releases Ca2+ from
intracellular Ca2+ stores by activating specific receptors on the membranes of these stores …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Ca2+ is one of the most important messengers. It transmits signals inside living cells and
takes part in intercellular coordination. The dynamics of the Ca2+ concentration shows a …

Autosomal dominant polycystic kidney disease, a common cause of renal failure, arises from
mutations in either the PKD1 or the PKD2 gene. The precise function of both PKD gene …

Background: Ca 2+ waves allow effective delivery of intracellular Ca 2+ signals to cytosolic
targets. Propagation of these regenerative Ca 2+ signals probably results from the activation …

Inositol (1, 4, 5)‐trisphosphate (IP 3) evokes Ca 2+ liberation in Xenopus oocytes as
elementary events (Ca 2+ puffs) that become coupled to propagate Ca 2+ waves with …

Ca2+ liberation through inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) plays a universal
role in cell regulation, and specificity of cell signalling is achieved through the …

Abstract Ryanodine and inositol 1, 4, 5-trisphosphate (IP 3) receptors–two related families of
Ca 2+ channels responsible for release of Ca 2+ from intracellular stores [1]–are …