[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2023 - pmc.ncbi.nlm.nih.gov
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Dynamics of atrial fibrillation mechanisms and comorbidities

J Heijman, D Linz, U Schotten - Annual review of physiology, 2021 - annualreviews.org
Atrial fibrillation (AF) contributes to morbidity and mortality of millions of individuals. Its
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …

Efficacy and safety of hybrid epicardial and endocardial ablation versus endocardial ablation in patients with persistent and longstanding persistent atrial fibrillation: a …

N Doll, T Weimar, DA Kosior, A Bulava… - …, 2023 - thelancet.com
Background Endocardial catheter ablation (CA) has limited long-term benefit for persistent
and longstanding persistent atrial fibrillation (PersAF/LSPAF). We hypothesized hybrid …

Electrophysiological consequences of cardiac fibrosis

S Verheule, U Schotten - Cells, 2021 - mdpi.com
For both the atria and ventricles, fibrosis is generally recognized as one of the key
determinants of conduction disturbances. By definition, fibrosis refers to an increased …

Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart …

A Goette, D Corradi, D Dobrev, L Aguinaga… - Europace, 2024 - academic.oup.com
Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …

Physics-informed neural networks to learn cardiac fiber orientation from multiple electroanatomical maps

C Ruiz Herrera, T Grandits, G Plank… - Engineering with …, 2022 - Springer
We propose FiberNet, a method to estimate in-vivo the cardiac fiber architecture of the
human atria from multiple catheter recordings of the electrical activation. Cardiac fibers play …

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation

B Maesen, S Verheule, S Zeemering, M La Meir… - EP …, 2022 - academic.oup.com
Aims Although in persistent atrial fibrillation (AF) a complex AF substrate characterized by a
high incidence of conduction block has been reported, relatively little is known about AF …

Fibrosis, atrial fibrillation and stroke: clinical updates and emerging mechanistic models

PM Boyle, JC Del Álamo, N Akoum - Heart, 2021 - heart.bmj.com
The current paradigm of stroke risk assessment and mitigation in patients with atrial
fibrillation (AF) is centred around clinical risk factors which, in the presence of AF, lead to …

Quantitative assessment of transmural fibrosis profile in the human atrium: evidence for a three-dimensional arrhythmic substrate by slice-to-slice histology

F Ravelli, M Masè, A Cristoforetti, L Avogaro… - Europace, 2023 - academic.oup.com
Aims Intramural fibrosis represents a crucial factor in the formation of a three-dimensional
(3D) substrate for atrial fibrillation (AF). However, the transmural distribution of fibrosis and …

Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium

A Roy, M Varela, H Chubb, R MacLeod… - PLoS computational …, 2020 - journals.plos.org
Clinical evidence suggests a link between fibrosis in the left atrium (LA) and atrial fibrillation
(AF), the most common sustained arrhythmia. Image-derived fibrosis is increasingly used for …