[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Dynamics of atrial fibrillation mechanisms and comorbidities
Atrial fibrillation (AF) contributes to morbidity and mortality of millions of individuals. Its
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …
Efficacy and safety of hybrid epicardial and endocardial ablation versus endocardial ablation in patients with persistent and longstanding persistent atrial fibrillation: a …
N Doll, T Weimar, DA Kosior, A Bulava… - …, 2023 - thelancet.com
Background Endocardial catheter ablation (CA) has limited long-term benefit for persistent
and longstanding persistent atrial fibrillation (PersAF/LSPAF). We hypothesized hybrid …
and longstanding persistent atrial fibrillation (PersAF/LSPAF). We hypothesized hybrid …
Electrophysiological consequences of cardiac fibrosis
S Verheule, U Schotten - Cells, 2021 - mdpi.com
For both the atria and ventricles, fibrosis is generally recognized as one of the key
determinants of conduction disturbances. By definition, fibrosis refers to an increased …
determinants of conduction disturbances. By definition, fibrosis refers to an increased …
Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart …
A Goette, D Corradi, D Dobrev, L Aguinaga… - Europace, 2024 - academic.oup.com
Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …
literature since its first mention in 1972. Since then, publications using the term were …
Physics-informed neural networks to learn cardiac fiber orientation from multiple electroanatomical maps
C Ruiz Herrera, T Grandits, G Plank… - Engineering with …, 2022 - Springer
We propose FiberNet, a method to estimate in-vivo the cardiac fiber architecture of the
human atria from multiple catheter recordings of the electrical activation. Cardiac fibers play …
human atria from multiple catheter recordings of the electrical activation. Cardiac fibers play …
Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation
B Maesen, S Verheule, S Zeemering, M La Meir… - EP …, 2022 - academic.oup.com
Aims Although in persistent atrial fibrillation (AF) a complex AF substrate characterized by a
high incidence of conduction block has been reported, relatively little is known about AF …
high incidence of conduction block has been reported, relatively little is known about AF …
Fibrosis, atrial fibrillation and stroke: clinical updates and emerging mechanistic models
The current paradigm of stroke risk assessment and mitigation in patients with atrial
fibrillation (AF) is centred around clinical risk factors which, in the presence of AF, lead to …
fibrillation (AF) is centred around clinical risk factors which, in the presence of AF, lead to …
Quantitative assessment of transmural fibrosis profile in the human atrium: evidence for a three-dimensional arrhythmic substrate by slice-to-slice histology
Aims Intramural fibrosis represents a crucial factor in the formation of a three-dimensional
(3D) substrate for atrial fibrillation (AF). However, the transmural distribution of fibrosis and …
(3D) substrate for atrial fibrillation (AF). However, the transmural distribution of fibrosis and …
Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium
Clinical evidence suggests a link between fibrosis in the left atrium (LA) and atrial fibrillation
(AF), the most common sustained arrhythmia. Image-derived fibrosis is increasingly used for …
(AF), the most common sustained arrhythmia. Image-derived fibrosis is increasingly used for …