The role of structural heterogeneity in the homodimerization of transmembrane proteins

A Majumder, JE Straub - The Journal of Chemical Physics, 2023 - pubs.aip.org
The equilibrium association of transmembrane proteins plays a fundamental role in
membrane protein function and cellular signaling. While the study of the equilibrium binding …

[HTML][HTML] Mapping the architecture of the initiating phosphoglycosyl transferase from S. enterica O-antigen biosynthesis in a liponanoparticle

GJ Dodge, AJ Anderson, Y He, W Liu, R Viner… - Elife, 2024 - elifesciences.org
Bacterial cell surface glycoconjugates are critical for cell survival and for interactions
between bacteria and their hosts. Consequently, the pathways responsible for their …

Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA

N Vuksanovic, JR Clasman, B Imperiali… - Protein …, 2024 - Wiley Online Library
In selected Campylobacter species, the biosynthesis of N‐linked glycoconjugates via the pgl
pathway is essential for pathogenicity and survival. However, most of the membrane …

Machine Learning Derived Collective Variables for the Study of Protein Homodimerization in Membrane

A Majumder, JE Straub - Journal of Chemical Theory and …, 2024 - ACS Publications
The accurate calculation of equilibrium constants for protein–protein association is of
fundamental importance to quantitative biology and remains an outstanding challenge for …