Extracellular vesicles (EVs), as nanometer-scale particles, include exosomes, microvesicles,
and apoptotic bodies. EVs are released by most cell types, such as bone marrow stem cells …

Millions of people worldwide suffer from osteoporosis, which causes bone fragility and
increases the risk of fractures. Osteoporosis is closely related to the inhibition of …

Exosomes are important transporters of miRNAs, which play varying roles in the healing of
the bone fracture. Angiogenesis is one of such critical events in bone healing, and we …

Inadequate vascularization of engineered tissue constructs is a main challenge in
developing a clinically impactful therapy for large, complex, and recalcitrant bone defects. It …

Calvaria from neonatal mouse and rat is ideal resource for osteoblasts but can be easily
contaminated by other cells such as fibroblasts. Here, we established a protocol for isolation …

Mesenchymal stem cells (MSC) are involved in the regeneration of various missing or
compromised periodontal tissues, including bone. MSC-derived conditioned medium (CM) …

Human adipose-derived mesenchymal stem cells (Ad-MSCs) have been proposed as
suitable option for cell-based therapies to support bone regeneration. In the bone …

The secretome present in the conditioned medium (CM) of mesenchymal stem cells (MSCs)
is a promising tool to be used in therapies to promote bone regeneration. Considering the …

Bioengineered bone designed to heal large defects requires concomitant development of
osseous and vascular tissue to ensure engraftment and survival. Adult human mesenchymal …

We investigated the effects of different implant biomaterials on cultured canine bone marrow
stromal cells (BMSC) undergoing differentiation into osteoblasts (dBMSC). BMSC were …