The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

Until recently, the purpose of studying microbes in pneumonia was the identification of an
organism that could assume the role of “pathogen” in disease. Common findings, using …

Bronchoalveolar lavage (BAL) is a key clinical and research tool in lung transplantation
(LTx). However, BAL collection and processing are not standardized across LTx centers …

Rationale: Recurrent wheeze and asthma are thought to result from alterations in early life
immune development following respiratory syncytial virus (RSV) infection. However, prior …

We hypothesized that the gut microbiota influences survival of murine cardiac allografts
through modulation of immunity. Antibiotic pretreated mice received vascularized cardiac …

Lung transplantation has developed significantly in recent years, but post-transplant care
and patients' survival still need to be improved. Moreover, organ shortage urges novel …

Ventilator-associated pneumonia (VAP) is one of the commonest hospital-acquired
infections associated with high mortality. VAP pathogenesis is closely linked to organisms …

Culture-independent study of the lower respiratory tract after lung transplantation has
enabled an understanding of the microbiome–that is, the collection of bacteria, fungi, and …

Introduction: The respiratory airways harbor a complex succession of ecological niches with
distinct but related bacterial communities. Particular challenges of respiratory microbiome …

Significant advances in culture-independent methods have expanded our knowledge about
the diversity of the lung microbial environment. Complex microorganisms and microbial …