Cancer cells originate from a series of acquired genetic mutations that can drive their
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …

The gut microbiota have long been recognized to play a key role in human health and
disease. Currently, several lines of evidence from preclinical to clinical research have …

The gut microbiota shapes the response to immune checkpoint inhibitors (ICIs) in cancer,
however dietary and geographic influences have not been well-studied in prospective trials …

Several non-redundant features of the tumour microenvironment facilitate
immunosuppression and limit anticancer immune responses. These include physical …

The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated
bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent …

The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Recent studies in both mice and humans have suggested that gut microbiota could
modulate tumor responsiveness to chemo-or immunotherapies. However, the underlying …

Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease
related to obesity, and causes liver disease and cancer,. The accumulation of metabolites …