Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably
overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) …

Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly
prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While …

Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous
system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in …

The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the
movement of water across biological membrane by osmosis, as well as facilitating the …

Network activity in the brain is associated with a transient increase in extracellular K+
concentration. The excess K+ is removed from the extracellular space by mechanisms …

Aquaporins (AQPs) are a family of membrane water channels that basically function as
regulators of intracellular and intercellular water flow. To date, thirteen AQPs, which are …

Three aquaporins are expressed in the brain. AQP4, the predominant brain water channel,
is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of …

The clearance function is essential for maintaining brain tissue homeostasis, and the
glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 …

Water homeostasis is fundamental for cell survival. Transport of water across cellular
membranes is governed by aquaporins—tetrameric integral membrane channels that are …

The aquaporin family of integral membrane proteins is composed of channels that mediate
cellular water flow. Aquaporin 4 (AQP4) is highly expressed in the glial cells of the central …