Over the last years, the pharmaceutical industry has faced real challenges regarding quality
assurance. In this context, the establishment of more holistic approaches to the …

Dermal disorders such as psoriasis and eczema are associated with modifications in the
chemical and molecular composition of the skin. Clobetasol propionate (CP), a superpotent …

Pulsatile drug delivery systems have drawn attention in contemporary research for
designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac …

Dolutegravir's therapeutic effectiveness in the management of neuroAIDS is mainly limited
by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as …

Bacterial vaginosis (BV) is a recurring infection that is difficult to treat due to the limited
bioavailability of antimicrobials. In this study, Metronidazole (MTZ)-loaded chitosan …

Abstract Background & Objectives Low penetration efficiency and retention time are the
main therapeutic concerns that make it difficult for most of the drugs to be delivered to the …

Rivastigmine, a reversible cholinesterase inhibitor, is frequently indicated in the
management of demented conditions associated with Alzheimer disease. The major hurdle …

As regulatory and technical landscapes for pharmaceutical formulation development are
rapidly evolving, a risk-management approach using multivariate analysis is highly essential …

Poor aqueous solubility besides extensive hepatic first effect significantly decreases the oral
absorption of levosulpiride, which in turn minimizes its therapeutic effectiveness. Niosomes …

Inclusion complexes (ICs) of metronidazole (MTZ) with β-cyclodextrin (BCD) and its
derivative 2-hydroxypropyl-β-cyclodextrin (HPBCD) were prepared to improve its apparent …