The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a
barrier that mediates microenvironment homeostasis. Deterioration of either the structure or …

Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with
improved bioavailability. Polydatin possesses potential biological activities predominantly …

Sepsis often results in damage to multiple organ systems, possibly due to severe
mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been …

Sepsis is the leading cause of death in the intensive care unit and continues to lack effective
treatment. It is widely accepted that high-mobility group box 1 (HMGB1) is a key …

Mitochondrial dysfunction has been implicated as a one of the major factors linked to the
development of painful diabetic neuropathy (DN). Several studies have demonstrated that …

Abstract Background Metabolic diseases (MDs), a series of chronic disorders, severely
decreases the quality of life for patients but also cause a heavy economic burden. Emerging …

Background & aims Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the
intestine endangering the health and survival of preterm infants. It is well established that the …

In a previous study, we demonstrated the role of polydatin (PD) in protecting against multiple
organ dysfunction in sepsis. The aim of this study is to investigate whether PD protects …

The neuroprotective effect of polydatin (PD) against hemorrhagic shock-induced
mitochondrial injury has been described previously, and mitochondrial dysfunction and …

Objectives. To ascertain if mitochondrial dysfunction (MD) of kidney cells is present in severe
hemorrhagic shock and to investigate whether polydatin (PD) can attenuate MD and its …