New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

[HTML][HTML] Neuroimmune signaling in alcohol use disorder

EK Erickson, EK Grantham, AS Warden… - Pharmacology …, 2019 - Elsevier
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

[HTML][HTML] Palmitoylethanolamide: a natural compound for health management

P Clayton, M Hill, N Bogoda, S Subah… - International journal of …, 2021 - mdpi.com
All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

[HTML][HTML] Lifestyle and metabolic syndrome: contribution of the endocannabinoidome

V Di Marzo, C Silvestri - Nutrients, 2019 - mdpi.com
Lifestyle is a well-known environmental factor that plays a major role in facilitating the
development of metabolic syndrome or eventually exacerbating its consequences. Various …

[HTML][HTML] Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling

C Manca, B Boubertakh, N Leblanc, T Deschênes… - Journal of lipid …, 2020 - ASBMB
The gut microbiota is a unique ecosystem of microorganisms interacting with the host
through several biochemical mechanisms. The endocannabinoidome (eCBome), a complex …

[HTML][HTML] Obesity affects the microbiota–gut–brain axis and the regulation thereof by endocannabinoids and related mediators

N Forte, AC Fernández-Rilo, L Palomba… - International Journal of …, 2020 - mdpi.com
The hypothalamus regulates energy homeostasis by integrating environmental and internal
signals to produce behavioral responses to start or stop eating. Many satiation signals are …

The expanded endocannabinoid system/endocannabinoidome as a potential target for treating diabetes mellitus

A Veilleux, V Di Marzo, C Silvestri - Current Diabetes Reports, 2019 - Springer
Abstract Purpose of Review The endocannabinoid (eCB) system, ie the receptors that
respond to the psychoactive component of cannabis, their endogenous ligands and the …

Palmitoylethanolamide and cannabidiol prevent inflammation-induced hyperpermeability of the human gut in vitro and in vivo—A randomized, placebo-controlled …

DG Couch, H Cook, C Ortori, D Barrett… - Inflammatory bowel …, 2019 - academic.oup.com
Background and aims We aimed to examine, for the first time, the effect of cannabidiol (CBD)
and palmitoylethanolamide (PEA) on the permeability of the human gastrointestinal tract in …

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders

V Di Marzo - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-
arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid CB1 and CB2 …

[HTML][HTML] Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono …

C Depommier, RM Vitale, FA Iannotti, C Silvestri… - Cells, 2021 - mdpi.com
Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in
the context of obesity and associated metabolic disorders. Although a first proof-of-concept …