It has been a decade since it was discovered that primary cilia have an essential role in
Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that …

During mammalian embryonic development, primary cilia transduce and regulate several
signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most …

The primary cilium is an antenna-like, immotile organelle present on most types of
mammalian cells, which interprets extracellular signals that regulate growth and …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Although tumours initiate from oncogenic changes in a cancer cell, subsequent tumour
progression and therapeutic response depend on interactions between the cancer cells and …

Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

Primary cilia, microtubule-based sensory structures, orchestrate various critical signals
during development and tissue homeostasis. In view of the rising interest into the reciprocal …

Motile cilia are microtubule-based organelles that play important roles in most eukaryotes.
Although axonemal microtubules are sufficiently stable to withstand their beating motion, it …

Many proteins are known to promote ciliogenesis, but mechanisms that promote primary
cilia disassembly before mitosis are largely unknown. Here we identify a mechanism that …

Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed
by lung cancer. Given the importance of BC in public health, it is essential to identify …