Acute coronary syndromes (ACS) are a comprehensive disease concept characterized by
acute myocardial ischemia caused by disruption of coronary artery plaque and consequent …

Randomized trials may be designed and interpreted as single experiments or they may be
seen in the context of other similar or relevant evidence. The amount and complexity of …

Background Controversy continues concerning the choice of rhythm control vs rate control
treatment strategies for atrial fibrillation (AF). A recent clinical trial showed no difference in 5 …

Physicians and insurers need to weigh the effectiveness of new drugs against existing
therapeutics in routine care to make decisions about treatment and formularies. Because …

Background: Patients with ischemic heart disease and preserved ventricular function
experience considerable morbidity and mortality despite standard medical therapy. Purpose …

Objectives: The purpose of this study was to investigate the prognostic value of change in
distance walked in 6 min in chronic heart failure (CHF). Background: The strongest …

Pharmacoepidemiology investigates associations between time‐varying medication
use/dose and risk of adverse events. Applied research typically relies on a priori chosen …

BACKGROUND AND OBJECTIVES: Accurate assessment of medication impact requires
modeling cumulative effects of exposure duration and dose; however, postmarketing studies …

Importance Although better pain management has guided policies for opioid use over the
past few decades, evidence is limited regarding how patterns of use are associated with the …

Computational chemical methods have been used to correlate the molecular properties of
the 10 ACE inhibitors (captopril, enalapril, perindopril, lisinopril, ramipril, trandolapril …