Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Experimental evidence from the past years highlights a key role for the intestinal microbiota
in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on …

The composition of the gut microbiota is in constant flow under the influence of factors such
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …

The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …

Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

Chronic inflammation is linked to the development of multiple cancers, including those of the
colon. Inflammation in the gut induces carcinogenic mutagenesis and promotes colorectal …

All nucleated cells express major histocompatibility complex I and interferon‐γ (IFNγ)
receptor, but an epithelial cell-specific function of IFNγ signalling or antigen presentation by …

Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of
tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in …

Fungi represent a significant proportion of the gut microbiota. Aberrant immune responses to
fungi are frequently observed in inflammatory bowel diseases (IBD) and colorectal cancer …

Despite great progress has been made in treatment strategies, colorectal cancer (CRC)
remains the predominant life-threatening malignancy with the feature of high morbidity and …