Each protein must be synthesized with the correct amino acid sequence, folded into its
native structure, and transported to a relevant subcellular location and protein complex. If …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Biomolecular condensates are membraneless structures formed through phase separation.
Recent studies have demonstrated that the material properties of biomolecular condensates …

The cytoplasm is densely packed with molecules that contribute to its nonideal behavior.
Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and …

Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …

The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …

Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly. Contemporary treatments can only relieve symptoms but fail to delay disease …

Protein homeostasis is vital for organisms and requires chaperones like the conserved Bcl-2-
associated athanogene (BAG) co-chaperones that bind to the heat shock protein 70 …

Biomolecular condensates are membraneless cellular compartments generated by phase
separation that regulate a broad variety of cellular functions by enriching some biomolecules …

Biomolecular condensation of proteins contributes to the organization of the cytoplasm and
nucleoplasm. A number of condensation processes appear to be directly involved in …