The chaperone-assisted selective autophagy complex dynamics and dysfunctions
B Tedesco, L Vendredy, V Timmerman, A Poletti - Autophagy, 2023 - Taylor & Francis
Each protein must be synthesized with the correct amino acid sequence, folded into its
native structure, and transported to a relevant subcellular location and protein complex. If …
native structure, and transported to a relevant subcellular location and protein complex. If …
Disrupting pathologic phase transitions in neurodegeneration
BT Hurtle, L Xie, CJ Donnelly - The Journal of clinical …, 2023 - Am Soc Clin Investig
Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …
relationship between insoluble protein accumulations and the resulting deficits in neurologic …
Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response
K Morishita, K Watanabe, I Naguro, H Ichijo - Cell Reports, 2023 - cell.com
Biomolecular condensates are membraneless structures formed through phase separation.
Recent studies have demonstrated that the material properties of biomolecular condensates …
Recent studies have demonstrated that the material properties of biomolecular condensates …
Molecular crowding: Physiologic sensing and control
AR Subramanya… - Annual Review of …, 2024 - annualreviews.org
The cytoplasm is densely packed with molecules that contribute to its nonideal behavior.
Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and …
Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and …
Theoretical and data-driven approaches for biomolecular condensates
Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …
mechanism that living cells use to organize biomolecules in time and space. These …
Biomolecular condensates in kidney physiology and disease
The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …
Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
WB Zang, HL Wei, WW Zhang, W Ma, J Li… - European Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly. Contemporary treatments can only relieve symptoms but fail to delay disease …
elderly. Contemporary treatments can only relieve symptoms but fail to delay disease …
[HTML][HTML] The oomycete-specific BAG subfamily maintains protein homeostasis and promotes pathogenicity in an atypical HSP70-independent manner
G Ai, J Si, Y Cheng, R Meng, Z Wu, R Xu, X Wang… - Cell Reports, 2023 - cell.com
Protein homeostasis is vital for organisms and requires chaperones like the conserved Bcl-2-
associated athanogene (BAG) co-chaperones that bind to the heat shock protein 70 …
associated athanogene (BAG) co-chaperones that bind to the heat shock protein 70 …
Critical Assessment of Condensate Boundaries in Dual-Color Single Particle Tracking
Biomolecular condensates are membraneless cellular compartments generated by phase
separation that regulate a broad variety of cellular functions by enriching some biomolecules …
separation that regulate a broad variety of cellular functions by enriching some biomolecules …
[HTML][HTML] Biomolecular condensation involving the cytoskeleton
S Mohapatra, S Wegmann - Brain Research Bulletin, 2023 - Elsevier
Biomolecular condensation of proteins contributes to the organization of the cytoplasm and
nucleoplasm. A number of condensation processes appear to be directly involved in …
nucleoplasm. A number of condensation processes appear to be directly involved in …