Meiotic recombination in mammals: localization and regulation
F Baudat, Y Imai, B De Massy - Nature Reviews Genetics, 2013 - nature.com
During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …
exchange of genetic material between homologous chromosomes. These exchanges …
Control of meiotic crossovers: from double-strand break formation to designation
Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …
Structure and repair of replication-coupled DNA breaks
Using CRISPR-Cas9 nicking enzymes, we examined the interaction between the replication
machinery and single-strand breaks, one of the most common forms of endogenous DNA …
machinery and single-strand breaks, one of the most common forms of endogenous DNA …
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
Abstract The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with
microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired …
microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired …
The landscape of mouse meiotic double-strand break formation, processing, and repair
Heritability and genome stability are shaped by meiotic recombination, which is initiated via
hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the …
hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the …
The configuration of RPA, RAD51, and DMC1 binding in meiosis reveals the nature of critical recombination intermediates
Meiotic recombination proceeds via binding of RPA, RAD51, and DMC1 to single-stranded
DNA (ssDNA) substrates created after formation of programmed DNA double-strand breaks …
DNA (ssDNA) substrates created after formation of programmed DNA double-strand breaks …
Genetic recombination is directed away from functional genomic elements in mice
Genetic recombination occurs during meiosis, the key developmental programme of
gametogenesis. Recombination in mammals has been recently linked to the activity of a …
gametogenesis. Recombination in mammals has been recently linked to the activity of a …
Initiation of meiotic recombination: how and where? Conservation and specificities among eukaryotes
B de Massy - Annual review of genetics, 2013 - annualreviews.org
Meiotic recombination is essential for fertility in most sexually reproducing species. This
process also creates new combinations of alleles and has important consequences for …
process also creates new combinations of alleles and has important consequences for …
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
The DNA-binding protein PRDM9 directs positioning of the double-strand breaks (DSBs)
that initiate meiotic recombination in mice and humans. Prdm9 is the only mammalian …
that initiate meiotic recombination in mice and humans. Prdm9 is the only mammalian …
Recombination initiation maps of individual human genomes
Introduction The dramatic events of meiotic recombination culminate in the exchange of
genetic information between parental chromosomes and ensure the production of …
genetic information between parental chromosomes and ensure the production of …