The ability of cells to sense and respond to mechanical signals is vital in development and
healthy tissue functioning. Many diseases are related to either changing mechanical …

Mechanical tension along the length of axons, dendrites, and glial processes has been
proposed as a major contributor to morphogenesis throughout the nervous system [DC Van …

Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

Recent studies have shown the importance of cell–substrate interaction on neurone
outgrowth, where the Young's modulus of the matrix plays a crucial role on the neurite …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

Increasing evidence suggests that mechanics play a critical role in regulating brain function
at different scales. Downstream integration of mechanical inputs into biochemical signals …

The brain is our most complex organ. During development, neurons extend axons, which
may grow over long distances along well-defined pathways to connect to distant targets. Our …

The establishment of a functioning neuronal network is a crucial step in neural development.
During this process, neurons extend neurites—axons and dendrites—to meet other neurons …

Morphogenesis of the nervous system involves a highly complex spatio-temporal pattern of
physical forces (mainly tension and pressure) acting on cells and tissues that are pliable but …

As one major component of extracellular matrix (ECM) in the central nervous system,
chondroitin sulfate proteoglycans (CSPGs) have long been known as inhibitors enriched in …