Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
[HTML][HTML] Cardiac fibrosis and fibroblasts
H Kurose - Cells, 2021 - mdpi.com
Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen.
Myofibroblasts are major players in the production of collagen, and are differentiated …
Myofibroblasts are major players in the production of collagen, and are differentiated …
Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …
Cardiac fibroblast diversity
MD Tallquist - Annual review of physiology, 2020 - annualreviews.org
Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …
Cardiac fibroblasts and mechanosensation in heart development, health and disease
The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …
into the coordinated regulation of intracellular signals, cellular function, gene expression …
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
C Sun, X Tian, Y Jia, M Yang, Y Li… - Open …, 2022 - royalsocietypublishing.org
Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are
able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) …
able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) …
Advances in ex situ tissue optical clearing
P Matryba, L Kaczmarek, J Gołąb - Laser & Photonics Reviews, 2019 - Wiley Online Library
Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …
development is necessary to decipher their biological complexity. However, until recently …
[HTML][HTML] Dual-functional hydrogel system for spinal cord regeneration with sustained release of arylsulfatase B alleviates fibrotic microenvironment and promotes …
Traumatic damage to the spinal cord does not spontaneously heal, often leading to
permanent tissue defects. We have shown that injection of imidazole-poly …
permanent tissue defects. We have shown that injection of imidazole-poly …
[HTML][HTML] Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism
G Geoghegan, J Simcox, MM Seldin, TJ Parnell… - Molecular …, 2019 - Elsevier
Abstract Objective Activation of the Wnt-signaling pathway is known to inhibit differentiation
in adipocytes. However, there is a gap in our understanding of the transcriptional network …
in adipocytes. However, there is a gap in our understanding of the transcriptional network …
Regulators of cardiac fibroblast cell state
R Bretherton, D Bugg, E Olszewski, J Davis - Matrix Biology, 2020 - Elsevier
Fibroblasts are the primary regulator of cardiac extracellular matrix (ECM). In response to
disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast …
disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast …