Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen.
Myofibroblasts are major players in the production of collagen, and are differentiated …

An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …

Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are
able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Traumatic damage to the spinal cord does not spontaneously heal, often leading to
permanent tissue defects. We have shown that injection of imidazole-poly …

Abstract Objective Activation of the Wnt-signaling pathway is known to inhibit differentiation
in adipocytes. However, there is a gap in our understanding of the transcriptional network …

Fibroblasts are the primary regulator of cardiac extracellular matrix (ECM). In response to
disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast …