PRMTs and arginine methylation: cancer's best-kept secret?
J Jarrold, CC Davies - Trends in molecular medicine, 2019 - cell.com
Post-translational modification (PTM) of proteins is vital for increasing proteome diversity
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …
[HTML][HTML] Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance
Y Zhu, T Xia, DQ Chen, X Xiong, L Shi, Y Zuo… - Drug Resistance …, 2024 - Elsevier
Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …
development of novel strategies to overcome it. Protein arginine methyltransferases …
The emerging role of PRMT6 in cancer
Z Chen, J Gan, Z Wei, M Zhang, Y Du, C Xu… - Frontiers in …, 2022 - frontiersin.org
Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic
regulation of gene expression through methylating histone or non-histone proteins, and …
regulation of gene expression through methylating histone or non-histone proteins, and …
[HTML][HTML] SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis
J Wang, X Yin, W He, W Xue, J Zhang… - Acta Pharmaceutica Sinica …, 2021 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is a common kidney malignancy characterized by a
poor prognosis. Suppressor of variegation 3–9 homolog 1 (SUV39H1), which encodes a …
poor prognosis. Suppressor of variegation 3–9 homolog 1 (SUV39H1), which encodes a …
A patent review of arginine methyltransferase inhibitors (2010–2018)
ABSTRACT Introduction: Protein arginine methyltransferases (PRMTs) are fundamental
enzymes that specifically modify the arginine residues of versatile substrates in cells. The …
enzymes that specifically modify the arginine residues of versatile substrates in cells. The …
Protein arginine methyltransferase 5 (PRMT5) as an anticancer target and its inhibitor discovery
Y Wang, W Hu, Y Yuan - Journal of medicinal chemistry, 2018 - ACS Publications
PRMT5 is a major enzyme responsible for symmetric dimethylation of arginine residues on
both histone and non-histone proteins, regulating many biological pathways in mammalian …
both histone and non-histone proteins, regulating many biological pathways in mammalian …
[HTML][HTML] PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
J Wang, C Wang, P Xu, X Li, Y Lu, D Jin, X Yin… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Background and Objective: Epigenetic alterations are common events in clear cell
renal cell carcinoma (ccRCC), and protein arginine methyltransferase 1 (PRMT1) is an …
renal cell carcinoma (ccRCC), and protein arginine methyltransferase 1 (PRMT1) is an …
[HTML][HTML] PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism
M Sun, L Li, Y Niu, Y Wang, Q Yan, F Xie, Y Qiao… - … Pharmaceutica Sinica B, 2023 - Elsevier
Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact
underlying mechanism and therapeutic potential are largely unknown. Here we report that …
underlying mechanism and therapeutic potential are largely unknown. Here we report that …
Protein arginine methyltransferases as therapeutic targets in hematological malignancies
C Sauter, J Simonet, F Guidez, B Dumétier, B Pernon… - Cancers, 2022 - mdpi.com
Simple Summary This review summarizes the current findings about the cellular roles of
protein arginine methyltransferases (PRMTs) in the formation of blood cells from stem cell …
protein arginine methyltransferases (PRMTs) in the formation of blood cells from stem cell …
Computer-aided drug design in epigenetics
Epigenetic dysfunction has been widely implicated in several diseases especially cancers
thus highlights the therapeutic potential for chemical interventions in this field. With rapid …
thus highlights the therapeutic potential for chemical interventions in this field. With rapid …