Data suggest that breast cancer growth is regulated by coordinated actions of the estrogen
receptor (ER) and various growth factor receptor signaling pathways. In tumors with active …

The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular
signaling events. Although these proteins do not have enzymatic or transcriptional activity …

Animal models are powerful tools to analyze the mechanism of the induction of human
breast cancer. Here we report a detailed analysis of mammary tumor progression in one …

Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly
observed in aggressive breast cancer and correlates with a poor prognosis. However, while …

Src family protein-tyrosine kinases, which play an important role in signal integration, have
been implicated in tumorigenesis in multiple lineages, including breast cancer. We …

Elevated expression of Akt-1 (PKBα) has been noted in a significant percentage of primary
human breast cancers. Another frequent event in the genesis of human breast cancers is …

When carcinoma cells metastasize, they change their phenotype to enhance motility. Cells
making this switch selectively express S100A4, a p53-associated, calcium-binding protein …

Adult mammary tissue has been considered “resting” with minimal morphological change.
Here, we reveal the dynamic nature of the nulliparous murine mammary gland. We …

Mice transgenic for the Polyomavirus middle T (PyV-mT) gene have been widely used to
study mammary tumorigenesis and metastasis. Although numerous molecular insights were …

The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and
correlates with poor prognosis. Mechanistically, FoxM1 associates with CBP to activate …