Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Compactness is an intrinsic property of objects. This feature is often associated with the old
and classical ratio perimeter2/area. This ratio is used in many scientific fields as shape …

Histology is the microscopic inspection of plant or animal tissue. It is a critical component in
diagnostic medicine and a tool for studying the pathogenesis and biology of processes such …

Three-dimensional (3D) reconstruction and examination of tissue at microscopic resolution
have significant potential to enhance the study of both normal and disease processes …

We demonstrate that many collective phenomena in multi-cellular systems can be explained
by models in which cells, despite their complexity, are represented as simple particles which …

Distant failure is the main cause of human cancer-related mortalities. To develop a model for
predicting distant failure in non-small cell lung cancer (NSCLC) and cervix cancer (CC) …

Toxicologic pathology is transitioning from analog to digital methods. This transition seems
inevitable due to a host of ongoing social and medical technological forces. Of these …

Motivation Digital pathology enables new approaches that expand beyond storage,
visualization or analysis of histological samples in digital format. One novel opportunity is 3D …

Follicular lymphoma (FL) is the second most common type of non-Hodgkin's lymphoma.
Manual histological grading of FL is subject to remarkable inter-and intra-reader variations …

Background Studying how individual cells spatially and temporally organize within the
embryo is a fundamental issue in modern developmental biology to better understand the …