The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we
age. Heart function gradually declines in old age, leading to continuous heart failure, even in …

Highlights•GPCRs can form homodimers or heterodimers; these complexes regulate a wide
range of physiological and pathological functions and are emerging drug targets.•The …

Over the years, numerous groups have employed human induced pluripotent stem cell-
derived cardiomyocytes (iPSC-CMs) as a superb human-compatible model for investigating …

Angiotensin II (Ang II) is formed by the action of angiotensin-converting enzyme (ACE) in the
renin–angiotensin system. This hormone is known to induce cardiac hypertrophy and heart …

We previously reported a series of macrocyclic analogues of [Pyr1]-apelin-13 (Ape13) with
increased plasma stability and potent APJ agonist properties. Based on the most promising …

Background MicroRNAs regulate cardiac hypertrophy development, which precedes and
predicts the risk of heart failure. microRNA‐204‐5p (miR‐204) is well expressed in …

The apelinergic system (AS) is a novel pleiotropic system with an essential role in renal and
cardiovascular physiology and disease, including water homeostasis and blood pressure …

The widely expressed G protein-coupled apelin receptor (APJ) is activated by two bioactive
endogenous peptides, apelin and ELABELA (ELA). The apelin/ELA-APJ-related pathway …

Heart failure is one of the most significant public health problems faced by millions of
medical researchers worldwide. And pathological cardiac hypertrophy is considered one of …