T cells engineered to express chimeric antigen receptors (CARs) that are specific for tumour
antigens have led to high complete response rates in patients with haematologic …

Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …

Activation-induced cell death (AICD) of T lymphocytes can be exploited by cancers to
escape immunological destruction. We demonstrated that tumor-specific cytotoxic T …

Long noncoding RNAs are emerging as important regulators of cellular functions, but little is
known of their role in the human immune system. Here we investigated long intergenic …

Abstract CD4+ T helper (TH) cells regulate appropriate cellular and humoral immune
responses to a wide range of pathogens and are central to the success of vaccines …

Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune
diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune …

The distinctive differentiated states of the CD4+ T helper cells are determined by the set of
transcription factors and the genes transcribed by the transcription factors. In vitro induction …

CD4+ helper T cells play crucial roles for host defense and immune-mediated disease by
their ability to differentiate into specialized subsets. These subsets attain restricted patterns …

How the immune system remembers a previous encounter with a pathogen and responds
more efficiently to a subsequent encounter has been one of the central enigmas for …

T helper cell differentiation occurs in the context of the extracellular cytokine milieu evoked
by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The …