Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics

T Ramasamy, HB Ruttala, S Munusamy… - Journal of Controlled …, 2022 - Elsevier
Cancer, infectious diseases, and metabolic and hereditary genetic disorders are a global
health burden affecting millions of people, with contemporary treatments offering limited …

Oxidative stress, neuroinflammation and mitochondria in the pathophysiology of amyotrophic lateral sclerosis

E Obrador, R Salvador, R López-Blanch… - Antioxidants, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron (MN) disease. Its primary
cause remains elusive, although a combination of different causal factors cannot be ruled …

Non-viral vector-mediated gene therapy for ALS: challenges and future perspectives

GR Ediriweera, L Chen, JJ Yerbury… - Molecular …, 2021 - ACS Publications
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, for which
no effective treatment is yet available to either slow or terminate it. Recent advances in gene …

[HTML][HTML] Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery

V Soubannier, G Maussion, M Chaineau, V Sigutova… - Neuroscience …, 2020 - Elsevier
Astrocytes play a number of key functions in health and disease. Activated astrocytes are
present in most, if not all, neurological diseases. Most current information on the …

Potential use of edaravone to reduce specific side effects of chemo-, radio-and immuno-therapy of cancers

C Bailly - International Immunopharmacology, 2019 - Elsevier
The drug edaravone (EDA) is prescribed for the treatment of patients with amyotrophic
lateral sclerosis or after an acute cerebral infarction. This synthetic pyrazolone derivative is a …

Improving the delivery of SOD1 antisense oligonucleotides to motor neurons using calcium phosphate-lipid nanoparticles

L Chen, C Watson, M Morsch, NJ Cole… - Frontiers in …, 2017 - frontiersin.org
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting the
upper and lower motor neurons in the motor cortex and spinal cord. Abnormal accumulation …

What does imaging reveal about the pathology of amyotrophic lateral sclerosis?

MR Turner, E Verstraete - Current neurology and neuroscience reports, 2015 - Springer
Amyotrophic lateral sclerosis (ALS) is now recognised to be a heterogeneous
neurodegenerative syndrome of the motor system and its frontotemporal cortical …

Current therapy of drugs in amyotrophic lateral sclerosis

H Lu, WD Le, YY Xie, XP Wang - Current neuropharmacology, 2016 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in
UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS …

Interplay of Metallome and Metabolome in Amyotrophic Lateral Sclerosis: A Study on Cerebrospinal Fluid of Patients Carrying Disease-Related Gene Mutations

N Solovyev, M Lucio, J Mandrioli, S Forcisi… - ACS Chemical …, 2023 - ACS Publications
Amyotrophic lateral sclerosis (ALS) is a lethal progressive neurodegenerative disease,
characterized by a loss of function of upper and lower motor neurons. This study aimed to …

Glutathione‐PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression …

KMS Kanhai, R Zuiker, I Stavrakaki… - British journal of …, 2018 - Wiley Online Library
Aims Intravenous high‐dose free methylprednisolone (MP) hemisuccinate is the primary
treatment for an acute relapse in relapsing–remitting multiple sclerosis. However, it is …