Radiopharmaceuticals for PET and SPECT imaging: a literature review over the last decade
G Crișan, NS Moldovean-Cioroianu… - International journal of …, 2022 - mdpi.com
Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …
imaging of several metabolic processes, blood flow measurements, regional chemical …
Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
The diagnosis of Alzheimer's disease can be improved by the use of biological measures.
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …
Tau PET imaging: present and future directions
Abnormal aggregation of tau in the brain is a major contributing factor in various
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of …
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of …
[HTML][HTML] Biomarkers for tau pathology
The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-
associated tau protein characterizes 80% of all dementia disorders, the most common …
associated tau protein characterizes 80% of all dementia disorders, the most common …
In vivo characterization and quantification of neurofibrillary tau PET radioligand 18F-MK-6240 in humans from Alzheimer disease dementia to young controls
Tau PET imaging has potential for elucidating changes in the deposition of
neuropathological tau aggregates that are occurring during the progression of Alzheimer …
neuropathological tau aggregates that are occurring during the progression of Alzheimer …
Cerebrospinal fluid clearance in Alzheimer disease measured with dynamic PET
Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is
involved in the pathophysiology of Alzheimer disease (AD) comes primarily from rodent …
involved in the pathophysiology of Alzheimer disease (AD) comes primarily from rodent …
Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
SP McCluskey, C Plisson, EA Rabiner… - European journal of …, 2020 - Springer
Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …
In vivo tau PET imaging in dementia: pathophysiology, radiotracer quantification, and a systematic review of clinical findings
In addition to the deposition of β-amyloid plaques, neurofibrillary tangles composed of
aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer's …
aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer's …
Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm
Purpose The aim of this study was to explore the cerebral distribution of the tau-specific PET
tracer [18 F] THK5317 (also known as (S)-[18 F] THK5117) retention in different stages of …
tracer [18 F] THK5317 (also known as (S)-[18 F] THK5117) retention in different stages of …