Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity …
GP Shenoy, R Pal, GSP Matada, E Singh… - Bioorganic …, 2023 - Elsevier
Discoidin domain receptors (DDRs) are one of the less explored targets for the treatment of
cancer which belong to receptor tyrosine kinases family. Discoidin domain receptors (DDRs) …
cancer which belong to receptor tyrosine kinases family. Discoidin domain receptors (DDRs) …
Design, synthesis, and biological evaluation of novel discoidin domain receptor inhibitors for the treatment of lung adenocarcinoma and pulmonary fibrosis
S Liu, X Li, C Chen, X Lin, W Zuo, C Peng… - European Journal of …, 2024 - Elsevier
Discoidin domain receptors (DDR) play crucial roles in cell proliferation and differentiation.
When DDRs are overexpressed, it has been associated with various diseases such as …
When DDRs are overexpressed, it has been associated with various diseases such as …
Research progress of DDR1 inhibitors in the treatment of multiple human diseases
M Liu, J Zhang, X Li, Y Wang - European Journal of Medicinal Chemistry, 2024 - Elsevier
Abstract Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine
kinase (RTK) and plays pivotal roles in regulating cellular functions such as proliferation …
kinase (RTK) and plays pivotal roles in regulating cellular functions such as proliferation …