At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein
classes. PC is the only phospholipid which is currently known to be required for lipoprotein …

How amphipathic phospholipids are shuttled between the membrane bilayer remains an
essential but elusive process, particularly at the endoplasmic reticulum (ER). One prominent …

Atherosclerosis is a chronic inflammatory disease promoted by hyperlipidemia. Several
studies support FOXP3-positive regulatory T cells (Tregs) as inhibitors of atherosclerosis; …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid
metabolism; activation of LXR induces transcription of lipogenic genes. This study shows …

The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …

Plasma triglyceride (TG) concentration is reemerging as an important cardiovascular
disease risk factor. More complete understanding of the genes and variants that modulate …

Low high‐density lipoprotein (HDL)‐cholesterol levels are associated with an increased risk
of coronary artery disease (CAD) and myocardial infarction, which has triggered the …

Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression
of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal …