A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment

X Wu, SJ Cobbina, G Mao, H Xu, Z Zhang… - … Science and Pollution …, 2016 - Springer
The rational for the study was to review the literature on the toxicity and corresponding
mechanisms associated with lead (Pb), mercury (Hg), cadmium (Cd), and arsenic (As) …

Heavy metal mixture exposure and effects in developing nations: an update

BO Anyanwu, AN Ezejiofor, ZN Igweze, OE Orisakwe - Toxics, 2018 - mdpi.com
The drive for development and modernization has come at great cost. Various human
activities in developed and developing countries, particularly in sub-Saharan Africa (SSA) …

In silico toxicology: computational methods for the prediction of chemical toxicity

AB Raies, VB Bajic - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Determining the toxicity of chemicals is necessary to identify their harmful effects on humans,
animals, plants, or the environment. It is also one of the main steps in drug design. Animal …

Expanded target-chemical analysis reveals extensive mixed-organic-contaminant exposure in US streams

PM Bradley, CA Journey, KM Romanok… - … science & technology, 2017 - ACS Publications
Surface water from 38 streams nationwide was assessed using 14 target-organic methods
(719 compounds). Designed-bioactive anthropogenic contaminants (biocides …

[HTML][HTML] Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in …

KJ Groh, RN Carvalho, JK Chipman, ND Denslow… - Chemosphere, 2015 - Elsevier
Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity
through levels of biological organization. By determining the linkages between toxicity …

Impact of heavy metal toxicity on the gut microbiota and its relationship with metabolites and future probiotics strategy: a review

P Bist, S Choudhary - Biological Trace Element Research, 2022 - Springer
The gut microbiota has a vital role in the maintenance of intestinal homeostasis. Several
studies have revealed that environmental exposure to pollutants such as heavy metals may …

Concentrations of persistent organic pollutants in maternal and cord blood from the maternal-infant research on environmental chemicals (MIREC) cohort study

M Fisher, TE Arbuckle, CL Liang, A LeBlanc… - Environmental …, 2016 - Springer
Background Pregnant women are an especially important population to monitor for
environmental exposures given the vulnerability of the developing fetus. During pregnancy …

Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice

H Ullah, A Khan, MW Baig, N Ullah, N Ahmed… - … medicine and therapies, 2020 - Springer
Background In the present study, the poncirin which is flavonoid-7-o-glycosides (isolated
from the Poncirus trifoliata) in nature was evaluated against the Carbon tetra chloride …

Exploration of computational approaches to predict the toxicity of chemical mixtures

S Kar, J Leszczynski - Toxics, 2019 - mdpi.com
Industrial advances have led to generation of multi-component chemicals, materials and
pharmaceuticals which are directly or indirectly affecting the environment. Although toxicity …

Metformin and other pharmaceuticals widespread in wadeable streams of the southeastern United States

PM Bradley, CA Journey, DT Button… - … & Technology Letters, 2016 - ACS Publications
Pharmaceutical contaminants are growing aquatic-health concerns and largely attributed to
wastewater treatment facility (WWTF) discharges. Five biweekly water samples from 59 …