With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

MolProbity is a structure-validation web service that provides broad-spectrum solidly based
evaluation of model quality at both the global and local levels for both proteins and nucleic …

The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a
more serious illness than influenza. The SARS-CoV-2 receptor binding domain (RBD) of the …

INTRODUCTION Activation of the STING (stimulator of interferon genes) protein by its
natural ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) …

Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family
of receptors that often undergo autoproteolysis to produce α and β subunits,–. A tethered …

Proton-coupled monocarboxylate transporters MCT1-4 catalyze the transmembrane
movement of metabolically essential monocarboxylates and have been targeted for cancer …

Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often
plasmid DNAs, from a donor cell to a recipient cell. It is the primary means by which …

The majority of oncogenic drivers are intracellular proteins, thus constraining their
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …

Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …

The prediction of RNA three‐dimensional structures remains an unsolved problem. Here, we
report assessments of RNA structure predictions in CASP15, the first CASP exercise that …